Cardiovascular diseases are still in the 1st place in the world among cause of deaths. Data accumulates about publications investigating the effect of radiation on cardiovascular disease. Ionized radiation is used for diagnosis and treatment of many disease, recently. As for invasive cardiology; coronary artery disease, cardiac valve diseases, electrophysiological studies require radiation assistance. It is very important for invasive cardiologists to know the cardiovascular adverse effects of radiation and radiation protection methods.

Aim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods:This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units)group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings. Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group. Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect.

Aim: Uric acid is the product of purine metabolism and elevated serum uric acid levels are associated with many metabolic conditions. In present retrospective analysis, we aimed to compare serum uric acid levels of well controlled type 2 diabetic subjects to those of poorly controlled type 2 DM patients.Methods: Medical database of type 2 diabetic subjects whom admitted to outpatient clinics of our institution, between January 2017 and August 2017, were retrospectively analyzed. Patients with anHbA1c level lower than 7, 5% were classified as well controlled and others were classified as poorly controlled type 2 DM group. Uric acid levels of the groups were compared.Results: Serum uric acid level of well controlled and poorly controlled diabetics were 4.1 (2, 8-5, 9) mg/dl and 5, 9(4-9, 6) mg/dl, respectively. The difference was statistically significant (p<0.001). A Pearson’s correlation test was revealed that serum uric acid was strongly and positively correlated with HbA1c (r=0.81, p<0.001).Conclusion: Serum uric acid levels worsen in poorly controlled type 2 diabetic subjects. Since HbA1c levels reflects changes in 3 months period, variations in serum uric acid levels could be used as a predictor of diabetic control level in shorter time periods.

Aim:To investigate the effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion (I/R) in rats.Method: Forty male Wistar rats were randomly divided into 4 groups as group I (sham, n=10), group II (control, n=10), group III (I/R-untreated, n=10) and group IV (I/R-cordycepin, n=10). Liver ischemia was induced for 30 min then reperfusion was allowed for 1 h. At the end of the experiment, liver specimens and blood samples were taken for histopathological and antioxidant evaluations, and biochemical analysis. Results: The levels of IL6, IL-1ß, and TNFa in the serum and liver tissues were higher in the I/R-untreated group compared to the I/R-cordycepin treated group. In the I/R-cordycepin group, serum MDA levels were decreased compared with the I/R-untreated group. The I/R-cordycepin treated group showed an increase in TAS levels, and a decrease in TOS levels compared with I/R-untreated group. The histopathological injury score were significantly lower in the I/R-cordycepin treated group compared to the I/R-untreated group. In the I/R-untreated group, the integrity of the hepatocyte cell lines deteriorated. Mononuclear inflammatory cells infiltrated the parenchyma regions, the sinuses dilated and there was diffuse congestion Preoperative treatment with cordycepine reduced histopathological abnormalities. Conclusion: Cordycepin has demonstrated significant hepatoprotective effects against I/R injury induced in rats through TAS elevation and reduction of TOS, MDA and proinflammatory cytokines.

Aim:To present the experience of treatment with Limberg flap procedure under spinal anesthesia in 23 young patients with pilonidal sinus disease.Methods:This was a retrospective study of 23 youngpatients who underwent surgery for pilonidal sinus diseaseunder spinal anesthesiabetween January 2011and November 2017 in the Division of Pediatric Surgery. All patients were evaluated for age, sex, clinical diagnosis, and body mass index, and infection, duration of symptoms, treatment, healing time, recurrences, complications and results. Results:Of the 23 patients,4 (17%) were male, and 19 (83%) were female. The mean age of the patients was 15.21 ± 2.8 years and the mean symptom duration was 4 ± 2.6 months. In 13 patients (56.5%), there was one or more sagittal lines in the midline and the mean sinus number of the patients was 2.12 ± 0.60. Pain was the most important complaint affecting the quality of life of the patient.The mean body mass index was 26.33 ± 2.54 kg / m2, and 47.8% (n = 11) were high BMI and 53.2% were normal BMI. One patient had temporary headache and one patient had urinary retention.Wound infection occurred in 2 patients (8.6%). Recurrence was not observed in patients. Conclusion:In this study, pilonidal sinus disease was treated with Limberg flap procedure under spinal anesthesia. The combination of these two applications in patients with pilonidal sinus may provide significant advantages, such as rapid recovery and short hospital stay, early return to daily activities, low complications, and recurrence rates.